Upfront transplantation may have better outcomes than pretransplant cytoreductive therapy for treating patients with <scp>MDS‐EB</scp> ‐1 or <scp>MDS‐EB</scp> ‐2

Patients With Heart Failure Readmitted to the Original Hospital Have Better Outcomes Than Those Readmitted Elsewhere

BACKGROUND Up to one fifth of readmissions after a heart failure hospitalization occur at a different hospital. This negatively impacts information continuity, but whether site of readmission impacts subsequent outcomes is unclear. METHODS AND RESULTS Retrospective cohort study of all patients discharged with a primary diagnosis of heart failure in Canada between April 2004 and December 2013....

Kidney transplantation in patients with diabetes: better than nothing

Pretransplant serum ferritin level may be a predictive marker for outcomes in patients having undergone allogeneic hematopoietic stem cell transplantation.

Iron overload increases the risk of infections, veno-occlusive disease and hepatic dysfunction in post-transplant period. Our objective was to investigate the association of pre-transplant ferritin levels with complications and survival after allogeneic hematopoietic stem cell transplantation (alloHSCT).We retrospectively analysed 84 patients' data who had undergone allogeneic HSCT into two gro...

Synaptotagmin: is 2 better than 1?

Editor's Note: These short reviews of a recent paper in the Journal, written exclusively by graduate students or postdoctoral fellows, are intended to mimic the journal clubs that exist in your own departments or institutions. For more information on the format and purpose of the Journal Club, please see Review of Pang et al. The synaptotagmin protein family, characterized by two C-terminal cal...

Particle Beam may have Higher Effectiveness in Treating Chemo-resistant Cancers than Low-LET Photon Beam Therapy.

It is now well-established that outcomes of radiotherapy depend on quality of radiation. A large body of experimental evidences suggests that high-LET (linear energy transfer) radiation or particle radiation has the ability to kill tumor cells more efficiently than low-LET photon beams such as X-rays and γ-rays [1,2]. The unique characteristics of particle beam, which includes precise dose dist...